Could Cannabidiol be Effective for Seizures?

Reem Gebrekidan, Mercer University College of Pharmacy

Dravet Syndrome is a genetic epileptic encephalopathy beginning in infancy that is characterized by febrile, prolonged, and lateralized seizures.[1] Epilepsy guidelines consider sodium valproate or topiramate as first-line treatment in children with Dravet syndrome while clobazam or stiripentol are supported as adjunctive therapy. Medications such as carbamazepine, gabapentin, lamotrigine, oxcarbazepine, phenytoin, pregabalin, tiagabine or vigabatrin were advised to be avoided. [2]
The U.S. Food and Drug Administration (FDA) has approved two synthetic cannabinoids based on a substance present in marijuana and a substance acting similarly to another compound in marijuana. Attempting to use components of marijuana is considered to be in the public’s best interest; however, safe and effective use has not been determined. [3] Continue reading

Topiramate and Motivational Enhancement Therapy for Cannabis use among youth: a randomized placebo-controlled pilot study

Sylvia Okoma, Mercer University College of Pharmacy

It is stated that topiramate is a medication that treats depression and alcohol, nicotine and cocaine addiction. [1, 2]

It has been noted that topiramate shows a high efficacy in the treatment of alcohol dependence and has a unique pharmacodynamic profile that gives it a broad range of effects in substance abuse related disorders.  However, it is stated that heterogeneity limits the effects of the drug in various types of substance abuse disorders.  [3]

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